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The GxGD Motif of Presenilin Contributes to Catalytic Function and Substrate Identification of γ-Secretase
γ-Secretase is a multisubunit aspartyl protease complex that catalyzes intramembrane cleavage of β-amyloid precursor protein (APP), a substrate key to Alzheimer's disease pathogenesis, and of Notch, a substrate crucial for cell differentiation. How γ-secretase recognizes and selects substrates...
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| Publié dans: | J Neurosci |
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| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Society for Neuroscience
2006
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6674133/ https://ncbi.nlm.nih.gov/pubmed/16597736 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5354-05.2006 |
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