The GxGD Motif of Presenilin Contributes to Catalytic Function and Substrate Identification of γ-Secretase

γ-Secretase is a multisubunit aspartyl protease complex that catalyzes intramembrane cleavage of β-amyloid precursor protein (APP), a substrate key to Alzheimer's disease pathogenesis, and of Notch, a substrate crucial for cell differentiation. How γ-secretase recognizes and selects substrates...

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Détails bibliographiques
Publié dans:J Neurosci
Auteurs principaux: Yamasaki, Aya, Eimer, Stefan, Okochi, Masayasu, Smialowska, Agata, Kaether, Christoph, Baumeister, Ralf, Haass, Christian, Steiner, Harald
Format: Artigo
Langue:Inglês
Publié: Society for Neuroscience 2006
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6674133/
https://ncbi.nlm.nih.gov/pubmed/16597736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5354-05.2006
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