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Presenilins mediate a dual intramembranous γ-secretase cleavage of Notch-1
Following ectodomain shedding, Notch-1 undergoes presenilin (PS)-dependent constitutive intramembranous endoproteolysis at site-3. This cleavage is similar to the PS-dependent γ-secretase cleavage of the β-amyloid precursor protein (βAPP). However, topological differences in cleavage resulting in am...
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| 主要な著者: | , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2002
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC129073/ https://ncbi.nlm.nih.gov/pubmed/12374741 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf541 |
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