Regulation of Notch Signaling by Dynamic Changes in the Precision of S3 Cleavage of Notch-1

Intramembrane proteolysis by presenilin-dependent γ-secretase produces the Notch intracellular cytoplasmic domain (NCID) and Alzheimer disease-associated amyloid-β. Here, we show that upon Notch signaling the intracellular domain of Notch-1 is cleaved into two distinct types of NICD species due to d...

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Bibliographic Details
Main Authors: Tagami, Shinji, Okochi, Masayasu, Yanagida, Kanta, Ikuta, Akiko, Fukumori, Akio, Matsumoto, Naohiko, Ishizuka-Katsura, Yoshiko, Nakayama, Taisuke, Itoh, Naohiro, Jiang, Jingwei, Nishitomi, Kouhei, Kamino, Kouzin, Morihara, Takashi, Hashimoto, Ryota, Tanaka, Toshihisa, Kudo, Takashi, Chiba, Shigeru, Takeda, Masatoshi
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2008
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2223315/
https://ncbi.nlm.nih.gov/pubmed/17967888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00863-07
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