Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as an amyloid-β accumulation modifier

Alzheimer’s disease (AD) is characterized by the accumulation of amyloid-β (Aβ). The genes that govern this process, however, have remained elusive. To this end, we combined distinct mouse strains with transcriptomics to directly identify disease-relevant genes. We show that AD model mice (APP-Tg) w...

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主要な著者: Morihara, Takashi, Hayashi, Noriyuki, Yokokoji, Mikiko, Akatsu, Hiroyasu, Silverman, Michael A., Kimura, Nobuyuki, Sato, Masahiro, Saito, Yuhki, Suzuki, Toshiharu, Yanagida, Kanta, Kodama, Takashi S., Tanaka, Toshihisa, Okochi, Masayasu, Tagami, Shinji, Kazui, Hiroaki, Kudo, Takashi, Hashimoto, Ryota, Itoh, Naohiro, Nishitomi, Kouhei, Yamaguchi-Kabata, Yumi, Tsunoda, Tatsuhiko, Takamura, Hironori, Katayama, Taiichi, Kimura, Ryo, Kamino, Kouzin, Hashizume, Yoshio, Takeda, Masatoshi
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2014
主題:
Biological Sciences
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3932848/
https://ncbi.nlm.nih.gov/pubmed/24497505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1307345111
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