Antifungal Activity of Eupolauridine and Its Action on DNA Topoisomerases

The azafluoranthene alkaloid eupolauridine has previously been shown to have in vitro antifungal activity and selective inhibition of fungal topoisomerase I. The present study was undertaken to examine further its selectivity and mode of action. Eupolauridine completely inhibits the DNA relaxation a...

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Autori principali: Khan, Shabana I., Nimrod, Alison C., Mehrpooya, Mohammed, Nitiss, John L., Walker, Larry A., Clark, Alice M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2002
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Mechanisms of Action: Physiological Effects
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC127229/
https://ncbi.nlm.nih.gov/pubmed/12019091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.6.1785-1792.2002
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