Antifungal Activity of Eupolauridine and Its Action on DNA Topoisomerases

The azafluoranthene alkaloid eupolauridine has previously been shown to have in vitro antifungal activity and selective inhibition of fungal topoisomerase I. The present study was undertaken to examine further its selectivity and mode of action. Eupolauridine completely inhibits the DNA relaxation a...

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Bibliografiske detaljer

Udgivet i:	Antimicrob Agents Chemother
Principais autores:	Khan, Shabana I., Nimrod, Alison C., Mehrpooya, Mohammed, Nitiss, John L., Walker, Larry A., Clark, Alice M.
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 2002
Fag:	Mechanisms of Action: Physiological Effects
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127229/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12019091/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.6.1785-1792.2002
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