Conversion of Topoisomerase I Cleavage Complexes on the Leading Strand of Ribosomal DNA into 5′-Phosphorylated DNA Double-Strand Breaks by Replication Runoff

Topoisomerase I cleavage complexes can be induced by a variety of DNA damages and by the anticancer drug camptothecin. We have developed a ligation-mediated PCR (LM-PCR) assay to analyze replication-mediated DNA double-strand breaks induced by topoisomerase I cleavage complexes in human colon carcin...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Strumberg, Dirk, Pilon, André A., Smith, Melanie, Hickey, Robert, Malkas, Linda, Pommier, Yves
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2000
Assuntos:	DNA Dynamics and Chromosome Structure
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC85758/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10805740/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.11.3977-3987.2000
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