Conversion of Topoisomerase I Cleavage Complexes on the Leading Strand of Ribosomal DNA into 5′-Phosphorylated DNA Double-Strand Breaks by Replication Runoff

Topoisomerase I cleavage complexes can be induced by a variety of DNA damages and by the anticancer drug camptothecin. We have developed a ligation-mediated PCR (LM-PCR) assay to analyze replication-mediated DNA double-strand breaks induced by topoisomerase I cleavage complexes in human colon carcin...

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Detaylı Bibliyografya
Asıl Yazarlar: Strumberg, Dirk, Pilon, André A., Smith, Melanie, Hickey, Robert, Malkas, Linda, Pommier, Yves
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2000
Konular:
DNA Dynamics and Chromosome Structure
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC85758/
https://ncbi.nlm.nih.gov/pubmed/10805740
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