Inhibition of Topoisomerase (DNA) I (TOP1): DNA Damage Repair and Anticancer Therapy

Most chemotherapy regimens contain at least one DNA-damaging agent that preferentially affects the growth of cancer cells. This strategy takes advantage of the differences in cell proliferation between normal and cancer cells. Chemotherapeutic drugs are usually designed to target rapid-dividing cell...

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Bibliografske podrobnosti

Principais autores:	Yang Xu, Chengtao Her
Format:	Artigo
Jezik:	Inglês
Izdano:	MDPI AG 2015-07-01
Serija:	Biomolecules
Teme:	topoisomerase (DNA) I (TOP1) anticancer therapy DNA replication topoisomerase inhibitor DNA double-strand break (DSB) DSB repair homologous recombination (HR) non-homologous end joining single-strand break (SSB) repair one-ended DSB
Online dostop:	http://www.mdpi.com/2218-273X/5/3/1652
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