Broadly cross-reactive HIV-1-neutralizing human monoclonal Fab selected for binding to gp120–CD4–CCR5 complexes

HIV-1 entry into cells involves formation of a complex between gp120 of the viral envelope glycoprotein (Env), a receptor (CD4), and a coreceptor, typically CCR5. Here we provide evidence that purified gp120(JR-FL)–CD4–CCR5 complexes exhibit an epitope recognized by a Fab (X5) obtained by selection...

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Main Authors: Moulard, Maxime, Phogat, Sanjay K., Shu, Yuuei, Labrijn, Aran F., Xiao, Xiaodong, Binley, James M., Zhang, Mei-Yun, Sidorov, Igor A., Broder, Christopher C., Robinson, James, Parren, Paul W. H. I., Burton, Dennis R., Dimitrov, Dimiter S.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC124503/
https://ncbi.nlm.nih.gov/pubmed/11997472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.102562599
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