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Broadly cross-reactive HIV-1-neutralizing human monoclonal Fab selected for binding to gp120–CD4–CCR5 complexes
HIV-1 entry into cells involves formation of a complex between gp120 of the viral envelope glycoprotein (Env), a receptor (CD4), and a coreceptor, typically CCR5. Here we provide evidence that purified gp120(JR-FL)–CD4–CCR5 complexes exhibit an epitope recognized by a Fab (X5) obtained by selection...
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| 主要な著者: | , , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The National Academy of Sciences
2002
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC124503/ https://ncbi.nlm.nih.gov/pubmed/11997472 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.102562599 |
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