Identification and Characterization of a Broadly Cross-Reactive HIV-1 Human Monoclonal Antibody That Binds to Both gp120 and gp41

Identification of broadly cross-reactive HIV-1-neutralizing antibodies (bnAbs) may assist vaccine immunogen design. Here we report a novel human monoclonal antibody (mAb), designated m43, which co-targets the gp120 and gp41 subunits of the HIV-1 envelope glycoprotein (Env). M43 bound to recombinant...

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Hlavní autoři: Zhang, Mei-Yun, Yuan, Tingting, Li, Jingjing, Rosa Borges, Andrew, Watkins, Jennifer D., Guenaga, Javier, Yang, Zheng, Wang, Yanping, Wilson, Richard, Li, Yuxing, Polonis, Victoria R., Pincus, Seth H., Ruprecht, Ruth M., Dimitrov, Dimiter S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3438192/
https://ncbi.nlm.nih.gov/pubmed/22970187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0044241
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