Bispecific Anti-HIV Immunoadhesins That Bind Gp120 and Gp41 Have Broad and Potent HIV-Neutralizing Activity

We have constructed bispecific immunoglobulin-like immunoadhesins that bind to both the HIV-envelope glycoproteins: gp120 and gp41. These immunoadhesins have N terminal domains of human CD4 engrafted onto the N-terminus of the heavy chain of human anti-gp41 mAb 7B2. Binding of these constructs to re...

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Detaylı Bibliyografya
Yayımlandı:Vaccines (Basel)
Asıl Yazarlar: Pincus, Seth H., Craig, Ryan B., Weachter, Lauren, LaBranche, Celia C., Nabi, Rafiq, Watt, Connie, Raymond, Mark, Peters, Tami, Song, Kejing, Maresh, Grace A., Montefiori, David C., Kozlowski, Pamela A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: MDPI 2021
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8310024/
https://ncbi.nlm.nih.gov/pubmed/34358190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/vaccines9070774
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