Bispecific Anti-HIV Immunoadhesins That Bind Gp120 and Gp41 Have Broad and Potent HIV-Neutralizing Activity

We have constructed bispecific immunoglobulin-like immunoadhesins that bind to both the HIV-envelope glycoproteins: gp120 and gp41. These immunoadhesins have N terminal domains of human CD4 engrafted onto the N-terminus of the heavy chain of human anti-gp41 mAb 7B2. Binding of these constructs to re...

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Detalhes bibliográficos
Publicado no:Vaccines (Basel)
Main Authors: Pincus, Seth H., Craig, Ryan B., Weachter, Lauren, LaBranche, Celia C., Nabi, Rafiq, Watt, Connie, Raymond, Mark, Peters, Tami, Song, Kejing, Maresh, Grace A., Montefiori, David C., Kozlowski, Pamela A.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8310024/
https://ncbi.nlm.nih.gov/pubmed/34358190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/vaccines9070774
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