Super Potent Bispecific Llama VHH Antibodies Neutralize HIV via a Combination of gp41 and gp120 Epitopes

Broad and potent neutralizing llama single domain antibodies (VHH) against HIV-1 targeting the CD4 binding site (CD4bs) have previously been isolated upon llama immunization. Here we describe the epitopes of three additional VHH groups selected from phage libraries. The 2E7 group binds to a new line...

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Bibliografski detalji
Izdano u:Antibodies (Basel)
Glavni autori: Strokappe, Nika M., Hock, Miriam, Rutten, Lucy, Mccoy, Laura E., Back, Jaap W., Caillat, Christophe, Haffke, Matthias, Weiss, Robin A., Weissenhorn, Winfried, Verrips, Theo
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2019
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6640723/
https://ncbi.nlm.nih.gov/pubmed/31544844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antib8020038
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