Super Potent Bispecific Llama VHH Antibodies Neutralize HIV via a Combination of gp41 and gp120 Epitopes

Broad and potent neutralizing llama single domain antibodies (VHH) against HIV-1 targeting the CD4 binding site (CD4bs) have previously been isolated upon llama immunization. Here we describe the epitopes of three additional VHH groups selected from phage libraries. The 2E7 group binds to a new line...

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Dettagli Bibliografici
Pubblicato in:Antibodies (Basel)
Autori principali: Strokappe, Nika M., Hock, Miriam, Rutten, Lucy, Mccoy, Laura E., Back, Jaap W., Caillat, Christophe, Haffke, Matthias, Weiss, Robin A., Weissenhorn, Winfried, Verrips, Theo
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6640723/
https://ncbi.nlm.nih.gov/pubmed/31544844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antib8020038
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