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Intestinal adenomas can develop with a stable karyotype and stable microsatellites
Loss of function of the adenomatous polyposis coli (APC)/Apc tumor suppressor gene occurs early in the etiology of intestinal cancer in mammals. In human colonic tumors, genomic instability is proposed to be associated with tumor initiation by inducing loss of APC function. We have used a mouse mode...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2002
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC124400/ https://ncbi.nlm.nih.gov/pubmed/12060718 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.132275099 |
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