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Intestinal adenomas can develop with a stable karyotype and stable microsatellites
Loss of function of the adenomatous polyposis coli (APC)/Apc tumor suppressor gene occurs early in the etiology of intestinal cancer in mammals. In human colonic tumors, genomic instability is proposed to be associated with tumor initiation by inducing loss of APC function. We have used a mouse mode...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2002
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC124400/ https://ncbi.nlm.nih.gov/pubmed/12060718 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.132275099 |
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