α-Catenin is essential in intestinal adenoma formation

A loss-of-function mutation in the APC gene initiates colorectal carcinogenesis. Although the molecular mechanism of tumor initiation is complex, several modifier genes have been identified using mouse models, including the ApcMin mouse. Among the familial adenomatous polyposis mouse lines carrying...

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Autori principali: Shibata, Hiroyuki, Takano, Hiroshi, Ito, Masaki, Shioya, Hisashi, Hirota, Morihisa, Matsumoto, Hiroshi, Kakudo, Yuichi, Ishioka, Chikashi, Akiyama, Tetsu, Kanegae, Yumi, Saito, Izumu, Noda, Tetsuo
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2007
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2084320/
https://ncbi.nlm.nih.gov/pubmed/17989230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0705730104
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