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High throughput RNAi screening identifies ID1 as a synthetic sick/lethal gene interacting with the common TP53 mutation R175H

The TP53 mutation (R175H) is one of the most common mutations in human cancer. It is a highly attractive strategy for cancer therapy to find the genes that lead the R175H-expressing cancer cells. The aim of this study was to identify the synthetic sick/lethal gene interacting with R175H. Using lenti...

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Bibliografske podrobnosti
Main Authors: IMAI, HIROO, KATO, SHUNSUKE, SAKAMOTO, YASUHIRO, KAKUDO, YUICHI, SHIMODAIRA, HIDEKI, ISHIOKA, CHIKASHI
Format: Artigo
Jezik:Inglês
Izdano: D.A. Spandidos 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3926671/
https://ncbi.nlm.nih.gov/pubmed/24378760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/or.2013.2953
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