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Induction of apoptosis by cytoplasmically localized wild-type p53 and the S121F mutant super p53
After DNA damage, p53 is accumulated in the nucleus and transactivates downstream genes and induces apoptosis. There are two pathways in p53-dependent apoptosis, the transactivation-dependent and -independent pathway. In this study, we constructed p53-inducible glioblastoma cell lines and analyzed t...
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
D.A. Spandidos
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3389701/ https://ncbi.nlm.nih.gov/pubmed/22783376 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2012.624 |
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