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Computational approaches for predicting the biological effect of p53 missense mutations: a comparison of three sequence analysis based methods

Prediction of the biological effect of missense substitutions has become important because they are often observed in known or candidate disease susceptibility genes. In this paper, we carried out a 3-step analysis of 1514 missense substitutions in the DNA-binding domain (DBD) of TP53, the most freq...

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Библиографические подробности
Главные авторы: Mathe, Ewy, Olivier, Magali, Kato, Shunsuke, Ishioka, Chikashi, Hainaut, Pierre, Tavtigian, Sean V.
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2006
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1390679/
https://ncbi.nlm.nih.gov/pubmed/16522644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkj518
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