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TP53 Mutations in Human Cancers: Origins, Consequences, and Clinical Use
Somatic mutations in the TP53 gene are one of the most frequent alterations in human cancers, and germline mutations are the underlying cause of Li-Fraumeni syndrome, which predisposes to a wide spectrum of early-onset cancers. Most mutations are single-base substitutions distributed throughout the...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2010
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2827900/ https://ncbi.nlm.nih.gov/pubmed/20182602 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a001008 |
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