Induction of apoptosis by cytoplasmically localized wild-type p53 and the S121F mutant super p53

After DNA damage, p53 is accumulated in the nucleus and transactivates downstream genes and induces apoptosis. There are two pathways in p53-dependent apoptosis, the transactivation-dependent and -independent pathway. In this study, we constructed p53-inducible glioblastoma cell lines and analyzed t...

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Main Authors: YASUDA, KATSUHIRO, KATO, SHUNSUKE, SAKAMOTO, YASUHIRO, WATANABE, GOU, MASHIKO, SATSUKI, SATO, ATSUKO, KAKUDO, YUICHI, ISHIOKA, CHIKASHI
Format: Artigo
Language:Inglês
Published: D.A. Spandidos 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3389701/
https://ncbi.nlm.nih.gov/pubmed/22783376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2012.624
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