Epigenetic phenotypes distinguish microsatellite-stable and -unstable colorectal cancers

Aberrant DNA methylation is a common phenomenon in human cancer, but its patterns, causes, and consequences are poorly defined. Promoter methylation of the DNA mismatch repair gene MutL homologue (MLH1) has been implicated in the subset of colorectal cancers that shows microsatellite instability (MS...

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Detalhes bibliográficos
Main Authors: Kuismanen, Shannon A., Holmberg, Mari T., Salovaara, Reijo, Schweizer, Pascal, Aaltonen, Lauri A., de la Chapelle, Albert, Nyström-Lahti, Minna, Peltomäki, Päivi
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1999
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC23037/
https://ncbi.nlm.nih.gov/pubmed/10535979
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