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Epigenetic phenotypes distinguish microsatellite-stable and -unstable colorectal cancers

Aberrant DNA methylation is a common phenomenon in human cancer, but its patterns, causes, and consequences are poorly defined. Promoter methylation of the DNA mismatch repair gene MutL homologue (MLH1) has been implicated in the subset of colorectal cancers that shows microsatellite instability (MS...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Kuismanen, Shannon A., Holmberg, Mari T., Salovaara, Reijo, Schweizer, Pascal, Aaltonen, Lauri A., de la Chapelle, Albert, Nyström-Lahti, Minna, Peltomäki, Päivi
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1999
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23037/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10535979/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.22.12661
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