Polyclonal structure of intestinal adenomas in Apc(Min)/+ mice with concomitant loss of Apc(+) from all tumor lineages

When tumors form in intestinal epithelia, it is important to know whether they involve single initiated somatic clones. Advanced carcinomas in humans and mice are known to be monoclonal. However, earlier stages of tumorigenesis may instead involve an interaction between cells that belong to separate...

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Bibliographic Details
Main Authors: Merritt, A. J., Gould, K. A., Dove, W. F.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences of the USA 1997
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC28409/
https://ncbi.nlm.nih.gov/pubmed/9391129
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