Deletion of cytosolic phospholipase A(2) suppresses Apc(Min)-induced tumorigenesis

Although nonsteroidal antiinflammatory drugs (NSAIDs) show great promise as therapies for colon cancer, a dispute remains regarding their mechanism of action. NSAIDs are known to inhibit cyclooxygenase (COX) enzymes, which convert arachidonic acid (AA) to prostaglandins (PGs). Therefore, NSAIDs may...

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Detalhes bibliográficos
Main Authors: Hong, Karen H., Bonventre, Joanna C., O'Leary, Eileen, Bonventre, Joseph V., Lander, Eric S.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2001
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC31157/
https://ncbi.nlm.nih.gov/pubmed/11274413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.051635898
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