Deletion of cytosolic phospholipase A(2) suppresses Apc(Min)-induced tumorigenesis

Although nonsteroidal antiinflammatory drugs (NSAIDs) show great promise as therapies for colon cancer, a dispute remains regarding their mechanism of action. NSAIDs are known to inhibit cyclooxygenase (COX) enzymes, which convert arachidonic acid (AA) to prostaglandins (PGs). Therefore, NSAIDs may...

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出版年:	Proc Natl Acad Sci U S A
主要な著者:	Hong, Karen H., Bonventre, Joanna C., O'Leary, Eileen, Bonventre, Joseph V., Lander, Eric S.
フォーマット:	Artigo
言語:	Inglês
出版事項:	National Academy of Sciences 2001
主題:	Biological Sciences
オンライン･アクセス:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC31157/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11274413/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.051635898
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