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A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression
The molecular mechanism for the anti-inflammatory action of theophylline is currently unknown, but low-dose theophylline is an effective add-on therapy to corticosteroids in controlling asthma. Corticosteroids act, at least in part, by recruitment of histone deacetylases (HDACs) to the site of activ...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC124399/ https://ncbi.nlm.nih.gov/pubmed/12070353 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.132556899 |
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