Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX

In mammalian cells, DNA double-strand breaks (DSBs) cause rapid phosphorylation of the H2AX core histone variant (to form γ-H2AX) in megabase chromatin domains flanking sites of DNA damage. To investigate the role of H2AX in mammalian cells, we generated H2AX-deficient (H2AX(Δ)(/)(Δ)) mouse embryoni...

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Hlavní autoři: Bassing, Craig H., Chua, Katrin F., Sekiguchi, JoAnn, Suh, Heikyung, Whitlow, Scott R., Fleming, James C., Monroe, Brianna C., Ciccone, David N., Yan, Catherine, Vlasakova, Katerina, Livingston, David M., Ferguson, David O., Scully, Ralph, Alt, Frederick W.
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 2002
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC123040/
https://ncbi.nlm.nih.gov/pubmed/12034884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.122228699
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