Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX

In mammalian cells, DNA double-strand breaks (DSBs) cause rapid phosphorylation of the H2AX core histone variant (to form γ-H2AX) in megabase chromatin domains flanking sites of DNA damage. To investigate the role of H2AX in mammalian cells, we generated H2AX-deficient (H2AX(Δ)(/)(Δ)) mouse embryoni...

Descrizione completa

Dettagli Bibliografici

Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Bassing, Craig H., Chua, Katrin F., Sekiguchi, JoAnn, Suh, Heikyung, Whitlow, Scott R., Fleming, James C., Monroe, Brianna C., Ciccone, David N., Yan, Catherine, Vlasakova, Katerina, Livingston, David M., Ferguson, David O., Scully, Ralph, Alt, Frederick W.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2002
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC123040/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12034884/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.122228699
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!