Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX

In mammalian cells, DNA double-strand breaks (DSBs) cause rapid phosphorylation of the H2AX core histone variant (to form γ-H2AX) in megabase chromatin domains flanking sites of DNA damage. To investigate the role of H2AX in mammalian cells, we generated H2AX-deficient (H2AX(Δ)(/)(Δ)) mouse embryoni...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Bassing, Craig H., Chua, Katrin F., Sekiguchi, JoAnn, Suh, Heikyung, Whitlow, Scott R., Fleming, James C., Monroe, Brianna C., Ciccone, David N., Yan, Catherine, Vlasakova, Katerina, Livingston, David M., Ferguson, David O., Scully, Ralph, Alt, Frederick W.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2002
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC123040/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12034884/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.122228699
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