Functional Interaction of H2AX, NBS1, and p53 in ATM-Dependent DNA Damage Responses and Tumor Suppression

Ataxia-telangiectasia (A-T) mutated (ATM) kinase signals all three cell cycle checkpoints after DNA double-stranded break (DSB) damage. H2AX, NBS1, and p53 are substrates of ATM kinase and are involved in ATM-dependent DNA damage responses. We show here that H2AX is dispensable for the activation of...

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Detalhes bibliográficos
Main Authors: Kang, Jian, Ferguson, David, Song, Hoseok, Bassing, Craig, Eckersdorff, Mark, Alt, Frederick W., Xu, Yang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC543410/
https://ncbi.nlm.nih.gov/pubmed/15632067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.2.661-670.2005
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