RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells

Duplexes of 21-nt RNAs, known as short-interfering RNAs (siRNAs), efficiently inhibit gene expression by RNA interference (RNAi) when introduced into mammalian cells. We show that siRNAs can be synthesized by in vitro transcription with T7 RNA polymerase, providing an economical alternative to chemi...

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Dades bibliogràfiques

Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Yu, Jenn-Yah, DeRuiter, Stacy L., Turner, David L.
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 2002
Matèries:	Biological Sciences
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC122899/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11972060/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.092143499
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