RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells

Duplexes of 21-nt RNAs, known as short-interfering RNAs (siRNAs), efficiently inhibit gene expression by RNA interference (RNAi) when introduced into mammalian cells. We show that siRNAs can be synthesized by in vitro transcription with T7 RNA polymerase, providing an economical alternative to chemi...

Täydet tiedot

Bibliografiset tiedot

Julkaisussa:	Proc Natl Acad Sci U S A
Päätekijät:	Yu, Jenn-Yah, DeRuiter, Stacy L., Turner, David L.
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	National Academy of Sciences 2002
Aiheet:	Biological Sciences
Linkit:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC122899/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11972060/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.092143499
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