The Survival of Motor Neurons Protein Determines the Capacity for snRNP Assembly: Biochemical Deficiency in Spinal Muscular Atrophy

Reduction of the survival of motor neurons (SMN) protein levels causes the motor neuron degenerative disease spinal muscular atrophy, the severity of which correlates with the extent of reduction in SMN. SMN, together with Gemins 2 to 7, forms a complex that functions in the assembly of small nuclea...

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Autors principals: Wan, Lili, Battle, Daniel J., Yong, Jeongsik, Gubitz, Amelie K., Kolb, Stephen J., Wang, Jin, Dreyfuss, Gideon
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2005
Matèries:
Gene Expression
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1156985/
https://ncbi.nlm.nih.gov/pubmed/15964810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.13.5543-5551.2005
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