Structure of a Key Intermediate of the SMN Complex Reveals Gemin2’s Crucial Function in snRNP Assembly

Assembly of heptameric Sm protein rings on snRNAs (Sm cores), essential for snRNP function, is mediated by the SMN complex. Specific Sm core assembly depends on Sm proteins and snRNA recognition by SMN/Gemin2- and Gemin5-containing subunits, respectively. The mechanism by which the Sm proteins are g...

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Bibliographic Details
Main Authors: Zhang, Rundong, So, Byung Ran, Li, Pilong, Yong, Jeongsik, Glisovic, Tina, Wan, Lili, Dreyfuss, Gideon
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3160754/
https://ncbi.nlm.nih.gov/pubmed/21816274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.06.043
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