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Gemin5 delivers snRNA precursors to the SMN complex for snRNP biogenesis
The SMN complex assembles Sm cores on snRNAs, a key step in the biogenesis of snRNPs, the spliceosome's major components. Here, using SMN complex inhibitors identified by high throughput screening and a ribo-proteomic strategy on formaldehyde crosslinked RNPs, we dissected this pathway in cells...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2901871/ https://ncbi.nlm.nih.gov/pubmed/20513430 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.03.014 |
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