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Gemin5 delivers snRNA precursors to the SMN complex for snRNP biogenesis

The SMN complex assembles Sm cores on snRNAs, a key step in the biogenesis of snRNPs, the spliceosome's major components. Here, using SMN complex inhibitors identified by high throughput screening and a ribo-proteomic strategy on formaldehyde crosslinked RNPs, we dissected this pathway in cells...

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Detalles Bibliográficos
Main Authors: Yong, Jeongsik, Kasim, Mumtaz, Bachorik, Jennifer L., Wan, Lili, Dreyfuss, Gideon
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2901871/
https://ncbi.nlm.nih.gov/pubmed/20513430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.03.014
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