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Structure of a Key Intermediate of the SMN Complex Reveals Gemin2’s Crucial Function in snRNP Assembly
Assembly of heptameric Sm protein rings on snRNAs (Sm cores), essential for snRNP function, is mediated by the SMN complex. Specific Sm core assembly depends on Sm proteins and snRNA recognition by SMN/Gemin2- and Gemin5-containing subunits, respectively. The mechanism by which the Sm proteins are g...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3160754/ https://ncbi.nlm.nih.gov/pubmed/21816274 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.06.043 |
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