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Structure of a Key Intermediate of the SMN Complex Reveals Gemin2’s Crucial Function in snRNP Assembly

Assembly of heptameric Sm protein rings on snRNAs (Sm cores), essential for snRNP function, is mediated by the SMN complex. Specific Sm core assembly depends on Sm proteins and snRNA recognition by SMN/Gemin2- and Gemin5-containing subunits, respectively. The mechanism by which the Sm proteins are g...

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Detalhes bibliográficos
Main Authors: Zhang, Rundong, So, Byung Ran, Li, Pilong, Yong, Jeongsik, Glisovic, Tina, Wan, Lili, Dreyfuss, Gideon
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3160754/
https://ncbi.nlm.nih.gov/pubmed/21816274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.06.043
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