Negative cooperativity between Gemin2 and RNA provides insights into RNA selection and the SMN complex's release in snRNP assembly

The assembly of snRNP cores, in which seven Sm proteins, D1/D2/F/E/G/D3/B, form a ring around the nonameric Sm site of snRNAs, is the early step of spliceosome formation and essential to eukaryotes. It is mediated by the PMRT5 and SMN complexes sequentially in vivo. SMN deficiency causes neurodegene...

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Bibliografske podrobnosti
izdano v:Nucleic Acids Res
Main Authors: Yi, Hongfei, Mu, Li, Shen, Congcong, Kong, Xi, Wang, Yingzhi, Hou, Yan, Zhang, Rundong
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2020
Teme:
RNA and RNA-protein complexes
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6954390/
https://ncbi.nlm.nih.gov/pubmed/31799625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz1135
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