The Survival of Motor Neurons Protein Determines the Capacity for snRNP Assembly: Biochemical Deficiency in Spinal Muscular Atrophy

Reduction of the survival of motor neurons (SMN) protein levels causes the motor neuron degenerative disease spinal muscular atrophy, the severity of which correlates with the extent of reduction in SMN. SMN, together with Gemins 2 to 7, forms a complex that functions in the assembly of small nuclea...

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Main Authors: Wan, Lili, Battle, Daniel J., Yong, Jeongsik, Gubitz, Amelie K., Kolb, Stephen J., Wang, Jin, Dreyfuss, Gideon
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2005
主題:
Gene Expression
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1156985/
https://ncbi.nlm.nih.gov/pubmed/15964810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.13.5543-5551.2005
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