Plasminogen-Binding Activity of Neuraminidase Determines the Pathogenicity of Influenza A Virus

When expressed in vitro, the neuraminidase (NA) of A/WSN/33 (WSN) virus binds and sequesters plasminogen on the cell surface, leading to enhanced cleavage of the viral hemagglutinin. To obtain direct evidence that the plasminogen-binding activity of the NA enhances the pathogenicity of WSN virus, we...

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Bibliographische Detailangaben
Hauptverfasser: Goto, Hideo, Wells, Krisna, Takada, Ayato, Kawaoka, Yoshihiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2001
Schlagworte:
Pathogenesis and Immunity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC114497/
https://ncbi.nlm.nih.gov/pubmed/11533192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.19.9297-9301.2001
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