Plasminogen-Binding Activity of Neuraminidase Determines the Pathogenicity of Influenza A Virus

When expressed in vitro, the neuraminidase (NA) of A/WSN/33 (WSN) virus binds and sequesters plasminogen on the cell surface, leading to enhanced cleavage of the viral hemagglutinin. To obtain direct evidence that the plasminogen-binding activity of the NA enhances the pathogenicity of WSN virus, we...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Goto, Hideo, Wells, Krisna, Takada, Ayato, Kawaoka, Yoshihiro
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2001
Assuntos:	Pathogenesis and Immunity
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC114497/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11533192/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.75.19.9297-9301.2001
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