Adaptation of Influenza A Viruses to Cells Expressing Low Levels of Sialic Acid Leads to Loss of Neuraminidase Activity

Influenza A viruses possess two virion surface proteins, hemagglutinin (HA) and neuraminidase (NA). The HA binds to sialyloligosaccharide viral receptors, while the NA removes sialic acids from the host cell and viral sialyloligosaccarides. Alterations of the HA occur during adaptation of influenza...

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Detalles Bibliográficos
Main Authors: Hughes, Mark T., McGregor, Martha, Suzuki, Takashi, Suzuki, Yasuo, Kawaoka, Yoshihiro
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2001
Assuntos:
Virus-Cell Interactions
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC114867/
https://ncbi.nlm.nih.gov/pubmed/11264365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.8.3766-3770.2001
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