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Adaptation of Influenza A Viruses to Cells Expressing Low Levels of Sialic Acid Leads to Loss of Neuraminidase Activity

Influenza A viruses possess two virion surface proteins, hemagglutinin (HA) and neuraminidase (NA). The HA binds to sialyloligosaccharide viral receptors, while the NA removes sialic acids from the host cell and viral sialyloligosaccarides. Alterations of the HA occur during adaptation of influenza...

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Bibliografische gegevens
Hoofdauteurs: Hughes, Mark T., McGregor, Martha, Suzuki, Takashi, Suzuki, Yasuo, Kawaoka, Yoshihiro
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2001
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC114867/
https://ncbi.nlm.nih.gov/pubmed/11264365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.8.3766-3770.2001
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