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Plasminogen-Binding Activity of Neuraminidase Determines the Pathogenicity of Influenza A Virus
When expressed in vitro, the neuraminidase (NA) of A/WSN/33 (WSN) virus binds and sequesters plasminogen on the cell surface, leading to enhanced cleavage of the viral hemagglutinin. To obtain direct evidence that the plasminogen-binding activity of the NA enhances the pathogenicity of WSN virus, we...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Microbiology
2001
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC114497/ https://ncbi.nlm.nih.gov/pubmed/11533192 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.19.9297-9301.2001 |
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