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A broadly protective human monoclonal antibody targeting the sialidase activity of influenza A and B virus neuraminidases

Broadly protective antibodies targeting influenza viruses are of interest as potential therapeutics or to inform vaccine development. Here the authors characterize a human mAb (DA03E17) with heterosubtypic binding to neuraminidases from IAVs and IBVs that provides broad protection in vitro and in vi...

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Autors principals: Atsuhiro Yasuhara, Seiya Yamayoshi, Maki Kiso, Yuko Sakai-Tagawa, Moe Okuda, Yoshihiro Kawaoka
Format: Artigo
Idioma:Inglês
Publicat: Nature Portfolio 2022-11-01
Col·lecció:Nature Communications
Accés en línia:https://doi.org/10.1038/s41467-022-34521-0
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