Balanced Hemagglutinin and Neuraminidase Activities Are Critical for Efficient Replication of Influenza A Virus

The SD0 mutant of influenza virus A/WSN/33 (WSN), characterized by a 24-amino-acid deletion in the neuraminidase (NA) stalk, does not grow in embryonated chicken eggs because of defective NA function. Continuous passage of SD0 in eggs yielded 10 independent clones that replicated efficiently. Charac...

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Main Authors: Mitnaul, Lyndon J., Matrosovich, Mikhail N., Castrucci, Maria R., Tuzikov, Alexander B., Bovin, Nikolai V., Kobasa, Darwyn, Kawaoka, Yoshihiro
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2000
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC112098/
https://ncbi.nlm.nih.gov/pubmed/10846083
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