Balanced Hemagglutinin and Neuraminidase Activities Are Critical for Efficient Replication of Influenza A Virus

The SD0 mutant of influenza virus A/WSN/33 (WSN), characterized by a 24-amino-acid deletion in the neuraminidase (NA) stalk, does not grow in embryonated chicken eggs because of defective NA function. Continuous passage of SD0 in eggs yielded 10 independent clones that replicated efficiently. Charac...

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Bibliografske podrobnosti

izdano v:	J Virol
Principais autores:	Mitnaul, Lyndon J., Matrosovich, Mikhail N., Castrucci, Maria R., Tuzikov, Alexander B., Bovin, Nikolai V., Kobasa, Darwyn, Kawaoka, Yoshihiro
Format:	Artigo
Jezik:	Inglês
Izdano:	American Society for Microbiology (ASM) 2000
Teme:	Virus-Cell Interactions
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC112098/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10846083/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.13.6015-6020.2000
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