Balanced Hemagglutinin and Neuraminidase Activities Are Critical for Efficient Replication of Influenza A Virus

The SD0 mutant of influenza virus A/WSN/33 (WSN), characterized by a 24-amino-acid deletion in the neuraminidase (NA) stalk, does not grow in embryonated chicken eggs because of defective NA function. Continuous passage of SD0 in eggs yielded 10 independent clones that replicated efficiently. Charac...

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Dades bibliogràfiques

Publicat a:	J Virol
Autors principals:	Mitnaul, Lyndon J., Matrosovich, Mikhail N., Castrucci, Maria R., Tuzikov, Alexander B., Bovin, Nikolai V., Kobasa, Darwyn, Kawaoka, Yoshihiro
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Microbiology (ASM) 2000
Matèries:	Virus-Cell Interactions
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC112098/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10846083/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.13.6015-6020.2000
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