Protein disulphide-isomerase reduces ricin to its A and B chains in the endoplasmic reticulum

Cells expressing ricin B chain within the secretory pathway are significantly more resistant to intoxication by ricin holotoxin but not to other cytotoxins that exploit similar endocytic routes to the cytosol. Furthermore, cells expressing the related B chain of abrin are protected against both inco...

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Hauptverfasser: Spooner, Robert A., Watson, Peter D., Marsden, Catherine J., Smith, Daniel C., Moore, Katherine A. H., Cook, Jonathon P., Lord, J. Michael, Roberts, Lynne M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Portland Press Ltd. 2004
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1134069/
https://ncbi.nlm.nih.gov/pubmed/15225124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20040742
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